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Dose-Response, Binding, Quantal, Toxicity & Potency Curves – Pharmacodynamics

by Pravin Shukle, MD
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    About the Lecture

    The lecture Dose-Response, Binding, Quantal, Toxicity & Potency Curves – Pharmacodynamics by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics. It contains the following chapters:

    • Response Curves
    • Binding and Quantal Curve
    • Spare Receptors
    • Toxicity Curves
    • Potency Curves
    • Question to Potency Curves
    • Question: Pharmacologic Parameters

    Included Quiz Questions

    1. The binding affinity of the new drug is much higher than the binding affinity of the old drug.
    2. The strength of the new drug is greater than the strength of the old drug.
    3. The toxicity of the new drug is definitely greater than the toxicity of the old drug.
    4. More people in a population will respond to the new drug than the old drug.
    1. Make each tablet 325 mg, with the recommendation to take one to two tablets. Half of people will respond to 325 mg, and almost all people will respond to 650 mg.
    2. Make each tablet 325 mg, because most people will respond to 325 mg.
    3. Make each tablet 325 mg. The toxic dose is 650 mg. You should only take one pill per day.
    1. Jill has taken a medication to which she possesses spare receptors.
    2. Jill has taken a medication that is not effective.
    3. Jill has taken a medication that has a high binding affinity but a low effectiveness.
    1. If the Kd of Drug X was 200 pg/ml that would mean a greater affinity.
    2. Kd represents the concentration at which 50% of the drug is ionized.
    3. Drug X produces 100% of the maximal effect when 50% of the receptors are bound.
    4. EC50 represents the point at which 50% of the population will have a toxic effect to the drug.
    5. Drug X requires that all receptors be bound to produce 50% of the maximal effect.

    Author of lecture Dose-Response, Binding, Quantal, Toxicity & Potency Curves – Pharmacodynamics

     Pravin Shukle, MD

    Pravin Shukle, MD


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    not your best video :/
    By Amir W. on 01. October 2017 for Dose-Response, Binding, Quantal, Toxicity & Potency Curves – Pharmacodynamics

    the lecture could be better it was hard to understand all the curves.. and the answer for the question was not so clear

     
    the lecture need to be more clarified
    By ahmad h. on 16. September 2017 for Dose-Response, Binding, Quantal, Toxicity & Potency Curves – Pharmacodynamics

    i think the topics of the lecture is not easy and it has a lot of new terms those need to be clarified more clearly

     
    Not super helpful.
    By Kathryn B. on 03. September 2017 for Dose-Response, Binding, Quantal, Toxicity & Potency Curves – Pharmacodynamics

    Too vague; I got the same basic information/presentation out of lecture. I was hoping for more clarification in these videos on topics like dose-response curves.