Pyrimidine de novo Metabolism: OMP Decarboxylase and Synthesis of UTP & CTP
About the Lecture
The lecture Pyrimidine de novo Metabolism: OMP Decarboxylase and Synthesis of UTP & CTP by Kevin Ahern, PhD is from the course Purine and Pyrimidine Metabolism.
Included Quiz Questions
Which of the following is true regarding de novo synthesis of pyrimidines? Select all options that apply.
- The second step is catalyzed by a regulatory enzyme.
- Aspartate and bicarbonate are the starting materials.
- CMP is the first pyrimidine made.
- The ring/pyrimidine base is synthesized after the attachment to a ribose-phosphate.
- UMP is the first pyrimidine synthesized.
Which of the following is true regarding the synthesis of UTP from UMP?
- All of the answers are true.
- Two sequential reactions are required.
- Two kinases are involved.
- Two ATPs are required.
- No regulation occurs.
Which of the following is true regarding the synthesis of CTP from UTP? Select all the options that apply.
- A transamination occurs.
- Two ATPs are required.
- No regulation occurs.
- It is an energy-producing reaction.
- It is catalyzed by CTP synthetase.
Which of the following is NOT a true statement regarding the de novo synthesis of pyrimidines?
- The OMP decarboxylase enzyme needs ATP as a co-factor to regulate the synthesis of pyrimidines.
- Orotidine monophosphate is the first pyrimidine intermediate metabolite that appears during the de novo synthesis of pyrimidines.
- The OMP decarboxylase enzyme fastens up the conversion of OMP to UMP 100 quadrillion times faster than an uncatalyzed reaction.
- The conversion of UTP to CTP involves a transamination reaction catalyzed by the CTP synthetase enzyme.
- The CTP synthetase enzyme is activated by GTP, whereas the CTP inhibits it to maintain the purine to pyrimidine balance in a cell.
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Author of lecture Pyrimidine de novo Metabolism: OMP Decarboxylase and Synthesis of UTP & CTP
Kevin Ahern, PhD
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First of all, I like the depth of this lecture and Professor Ahern is clearly very knowledgeable and concise on the the topic being discussed. And I also like due to the fact that this video is clearly a high-yield resource which is very helpful for my upcoming medical exam. However, I believe that this could have been better had the previous cycles preceding the formation of OMP explained as well in order for us the students to be able to get the essence of the information better. That's all I have got to say
