Nucleotide Metabolism and Thymidine Metabolism by Kevin Ahern, PhD

About the Lecture

The lecture Nucleotide Metabolism and Thymidine Metabolism by Kevin Ahern, PhD is from the course Purine and Pyrimidine Metabolism. It contains the following chapters:

Nucleotide Metabolism
Thymidine Metabolism

Included Quiz Questions

Which of the following occurs in allosteric control of ribonucleotide reductase?

The binding of dGTP at the allosteric site favors the binding of ADP at the active site.
The binding of dATP at the active site activates the enzyme.
The binding of dTTP at the allosteric site favors the binding of UDP at the active site.
The binding of dGTP at the allosteric site favors the binding of UDP at the active site.
There is no relationship between the binding of dGTP and ADP.

An abundance of the dATP in the cell leads to what?

The deactivation of ribonucleotide reductase.
The activation of ribonucleotide reductase.
The generation of ATP molecules via the activity of ribonucleotide reductase.
The generation of dAMP molecules via the activity of ribonucleotide reductase.
The generation of dGTP molecules via the activity of ribonucleotide reductase.

Which reaction does the enzyme dUTPase catalyze, and for what purpose is this reaction necessary?

It catalyzes the reaction from dUTP to dUMP; this is necessary to prevent its utilization via the DNA pol enzyme.
It catalyzes the reaction from dUMP to dUTP; this reaction makes it available for the DNA pol enzyme during replication.
It catalyzes the reaction from dUMP to dTMP; this reaction is needed to make it available for the DNA pol enzyme during replication.
It catalyzes the reaction from dTMP to dUMP; this needs to be available for the DNA pol enzyme during replication.
It catalyzes the reaction from dUTP to dTTP; this is required for the DNA pol enzyme during replication.