Nucleotide Metabolism: Introduction and De novo Purine Metabolism
About the Lecture
The lecture Nucleotide Metabolism: Introduction and De novo Purine Metabolism by Kevin Ahern, PhD is from the course Purine and Pyrimidine Metabolism. It contains the following chapters:
- Nucleotide Metabolism - Introduction
- De novo Purine Metabolism
- Building a Purine Ring
Included Quiz Questions
Which of the following are true regarding nucleotides? Select all that apply
- They are made by de novo and salvage pathways.
- They are made in separate, non-overlapping pathways for each nucleotide.
- They can have any of three purines or two pyrimidines.
- Structurally, pyrimidines have two rings, and purines have one.
- They are the building blocks of DNA and RNA.
Which of the following is true regarding purine synthesis?
- All of the answers are true.
- PRPP synthetase catalyzes the process that converts ATP to AMP.
- It begins with ribose-5-phosphate.
- It includes the intermediate known as IMP.
- It consumes ATP.
Which of the following does NOT take part in ATP and GTP synthesis?
- Gluteraldehyde
- Glycine and glutamine
- CO2
- Aspartate
- N10-formyl-THF
Which of the following is NOT correctly associated regarding ATP and GTP synthesis?
- N10-formyl-THF — source of N atoms in purine synthesis
- Ribose-5-phosphate — starting point
- Inosine monophosphate — branch point between ATP and GTP synthesis
- PRPP synthetase — regulatory enzyme for purine synthesis
- PRPP amidotransferase — helpful in synthesis of phosphoribosylamine
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Author of lecture Nucleotide Metabolism: Introduction and De novo Purine Metabolism
Kevin Ahern, PhD
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Thanks for focusing on the "big picture!" The lecturer at my school bogged us down with the details, so it was hard to take in what the most important steps were
