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Anti-HIV Agents: Nucleoside Reverse Transcriptase Inhibitors (NRTI) – Antiviral Drugs

by Pravin Shukle, MD
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    The next category of medication are the Reverse Transcriptase Inhibitors. These are probably the most famous of the category. And probably the ones that I think will be tested upon most in exams. They are divided into the NRTI's and the NNRTI's. Now they are inhibiting nucleic acid synthesis. Let's take a look at the list of these medications. You can notice that you'll probably recognize some of these agents and I have underlined the ones that I think are probably the most important. The other thing I want to point out on this list of medications is that three letter designation that you see after each of the words or after each of the names. We have started to use three letter designations for medications both in antiviral therapy and in cancer chemotherapy to identify agents with a specific code. That way we don't have to write out the whole name when we are writing out prescriptions. So there you have the list. I think the most famous of these is probably didasosine or DDI. When we take a look at these agents, we'll divide them up into nucleoside based reverse transcriptase agents and the non-nucleoside based reverse transcriptase inhibitors. Now the nucleoside based reverse transcriptase inhibitors are really antimetabolic drugs. So we often use three or more drugs at the same time from different classes. And this is usually used before the symptoms appear. The thing you want to remember about this medication regimen, is we call them HAART regimens or HAART which stands for Highly Active Anti Retroviral Therapy. Now we've shown to reduce significantly CD4 progression in with HAART therapy. And we also have shown that using HAART therapy we could significantly reduce death or morbidity and 5 year mortality rates. The nucleoside based reverse transcriptase...

    About the Lecture

    The lecture Anti-HIV Agents: Nucleoside Reverse Transcriptase Inhibitors (NRTI) – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.


    Author of lecture Anti-HIV Agents: Nucleoside Reverse Transcriptase Inhibitors (NRTI) – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD


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