00:02
Quickly, what does Nikolsky sign mean?
The risk or tendency of the
keratinocytes to separate.
00:08
That’s it.
00:10
If it’s positive, is that a
good thing or bad thing?
When is the last time you want to scrape
your skin and it comes right off?
It’s a bad thing.
00:18
So now, you tell me, which
one was the vulgar disease?
Pemphigus vulgaris.
00:22
That’s the one in which it would
then be positive Nikolsky sign.
00:26
What do we call this medically?
What if you don’t see the term Nikolsky?
Then you’ll hear the term achantolysis.
00:33
Allow the name to speak to you.
00:34
Lysis of your keratinocyte.
00:36
Clear?
Pressure is placed on the blister
or the skin at question.
00:43
If the blister spreads laterally, then
Nikolsky sign, obviously, is positive.
00:48
If it doesn’t, then it’s negative.
00:50
If it is positive, then you
know it’s pemphigus vulgaris.
00:52
If it’s negative, then high in your
differential is bullous pemphigoid,
and make sure that you take a
full history of your patient.