Opportunistic Fungal Infections

by Vincent Racaniello, PhD

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    Hello and welcome to Opportunistic Fungal Infections. After listening to this lecture, you'll be able to name some fungi that cause opportunistic infections. You will be familiar with the pathogenesis and the epidemiology of candidiasis cryptococcosis, aspergillosis and pneumocystosis, and you'll know which drugs can be used to treat opportunistic fungal infections. The first opportunistic infection we'll consider is candidiasis. Now opportunistic signifies that in most people, these fungi do not cause disease, it's only when there's an opportunity, such as immunosuppression, do they cause problems. And candidiasis may be caused by three different species of candida; Candida albicans, Candida glabrata and Candida parapsiloses. And these pictures of candida show the typical fluffy white appearance of the colonies on an agar plate, that's the picture on the left and on the right is in the microscope, you can see the single cells of Candida. So this can assume a yeast configuration, it can also assume a mycelial configuration. Candida species are normal inhabitants of our skin and our mucosal surfaces, such as our mouth and the genital tract. So here's a case where everybody has these bacteria, excuse me, everybody has these fungi, but in only certain situations do they cause disease. So, when is candidiasis a problem? Those individuals at risk for this disease include: the immunosuppressed, if you're having an organ transplant and you need to have drugs to reduce the risk of rejection of the organ, patients in intensive care units, the use of broad-spectrum antibiotics that can alter the normal microbial flora and allow certain species to overgrow, people who have kidney failure and they require dialysis and needles need to be inserted into these individuals repeatedly, that can introduce the candida below the surface of the skin, which is where it normally inhabits. Central intravenous...

    About the Lecture

    The lecture Opportunistic Fungal Infections by Vincent Racaniello, PhD is from the course Microbiology: Advanced. It contains the following chapters:

    • Opportunistic Fungal Infections
    • Candidiasis
    • Candidiasis - Diagnosis
    • Candidiasis - Treatment
    • Cryptococcosis
    • Aspergillosis
    • Pneumocystis Pneumonia (PCP)
    • Opportunistic Fungal Infections: Learning Outcomes

    Author of lecture Opportunistic Fungal Infections

     Vincent Racaniello, PhD

    Vincent Racaniello, PhD

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