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Hemolytic Anemia: Macro- and Microangiopathic Hemolytic Anemia – Red Blood Cell Pathology

by Carlo Raj, MD
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    What if you’re inside your blood vessel and you’re an RBC and you end up hitting an obstructive and your head was chopped off? That’s not very nice. Welcome to micro- and macroangiopathic hemolytic anemia, and what we’re going to do with our head being chopped off with an RBC, referring to a schistocyte, hence you should wear helmets. Helmet cells. Let’s continue. So what we have here is inside my blood vessel, and we’ll begin by looking at micro and macroangiopathic. It’s a mechanical damage. Meaning to say that this is not a problem within the RBC, so therefore you would then refer to this being an extrinsic problem. And by extrinsic, we mean that the issue is taking place outside the RBC. Where are you? In your blood vessel. So what is the difference between micro- and macroangiopathic? All it is quite simple. If it’s macroangiopathic, then it is your common, common diseases in our society secondary to hypertension or diabetes mellitus, in which, well, the larger blood vessels are undergoing obstruction or hyaline arteriolosclerosis, and there’s every possibility that an RBC might then get hurt and form a schistocyte. Or you can have little blood vessels that are undergoing thrombotic diseases where our focus shall be. So our focus, ladies and gentlemen, in this lecture series, will be in the format of microangiopathic. However, keep in mind, if it’s macroangiopathic type of hemolytic anemia, it only means that your patient has a systemic type of disease, either hypertension or diabetes mellitus, resulting in the same type of consequence where the RBCs are extrinsically becoming hurt. And the next question that you want to ask yourself is, well, would this be primarily a intravascular or extravascular type of disorder? It will primarily be an intravascular disorder, which means...

    About the Lecture

    The lecture Hemolytic Anemia: Macro- and Microangiopathic Hemolytic Anemia – Red Blood Cell Pathology by Carlo Raj, MD is from the course Hemolytic Anemia – Red Blood Cell Pathology (RBC). It contains the following chapters:

    • Micro/Macro Angiopathic Hemolytic Anemia - Etiology
    • Micro/Macro Angiopathic Hemolytic Anemia - Pathogenesis and Morphology
    • Micro/Macro Angiopathic Hemolytic Anemia - Schistocytes

    Included Quiz Questions

    1. Schistocyte
    2. Bite cell
    3. Spherocyte
    4. Burr cell
    5. Elliptocyte
    1. Behcet's disease
    2. Aortic stenosis
    3. Disseminated intravascular coagulation
    4. Diabetes mellitus
    5. Thrombotic thrombocytopenic purpura
    1. Bite cells
    2. Schistocyte
    3. Spherocyte
    4. Burr cell
    5. Elliptocyte

    Author of lecture Hemolytic Anemia: Macro- and Microangiopathic Hemolytic Anemia – Red Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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