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Lung Agenesis – Lung Development

by John McLachlan, PhD
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    00:00 smaller than it would normally be. In addition, we may also have agenesis, failure of the lungs to form altogether. This will be a result of complex interactions between signaling molecules. Now, in general, we are not going into the complexities of molecular signaling at this detailed level. So we merely note that here, we have particular agents, for instance, BMP-4, bone morphogenetic protein 4, which is responding to signals from the mesoderm through the fibroblast growth factor 10 and transforming growth factor beta 1.

    00:34 Another gene involved in the surrounding tissue is one called sonic hedgehog. Really, all I want to make clear here is that there are complex patterns of tissue signaling that take place. And a disturbance in the genetics for any one of these could lead to the lung failing to grow out or failing to bud properly. Normally, of course, the placenta is dealing with gas exchange during intrauterine life. So the baby will continue to develop perfectly normally even in the absence of lungs. And it could be a unilateral condition on one side of the body or bilateral on both sides of the body. Now, fortunately, bilateral lung agenesis is extremely rare because it is, of course, incompatible with subsequent survival after birth. So, let’s summarize what we’ve covered in this lecture. First of all, we looked at how lungs developed in the first place, and then we focused on the maturation of the lungs because in the case of the lungs, the state of histological differentiation is of absolutely vital clinical significance. We looked at major abnormalities and clinical problems that can arise when things go wrong in lung development, and touched in some of the ways in which one might recognize them. For instance, dribbling milk from the mouth on feeding or the abdomen extended on breathing. Finally, we looked at the clinical significance that some of these events might have during the course of development. Thank you.


    About the Lecture

    The lecture Lung Agenesis – Lung Development by John McLachlan, PhD is from the course System-Specific Embryology with John McLachlan.


    Author of lecture Lung Agenesis – Lung Development

     John McLachlan, PhD

    John McLachlan, PhD


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