Lipid Metabolism

I've reviewed the Video, and while it provides a comprehensive overview, there are a few points that need clarification. "Fatty acid synthesis doesn't occur in the mitochondrion; it occurs in the cytoplasm, sequestered from fatty acid oxidation, simplifying the regulation of the two pathways." Clarification: Fatty acid synthesis indeed occurs in the cytoplasm, separate from fatty acid oxidation that takes place in mitochondria. This separation allows for streamlined regulation, ensuring the balance between synthesis and breakdown. "Fatty acid synthesis is chemically similar to the reverse of oxidation, involving joining, reduction, loss of water, and a final reduction, making it essentially the reverse of oxidation." Clarification: Fatty acid synthesis does indeed involve joining of acetyl and malonyl units, reduction steps, and removal of water, making it similar but not exactly the reverse of oxidation. The subtle differences in the chemical steps are crucial for the controlled synthesis of fatty acids. "The enzyme acetyl-CoA carboxylase is regulated through phosphorylation by AMP-activated protein kinase and allosteric binding of citrate, ensuring the balance between synthesis and cellular energy levels." Clarification: Acetyl-CoA carboxylase, a key enzyme in fatty acid synthesis, is indeed regulated through phosphorylation and allosteric binding of citrate. This regulation allows cells to respond to energy demands, modulating fatty acid production accordingly. "Fatty acid synthesis involves a series of steps catalyzed by the multifunctional enzyme fatty acid synthase, where individual activities within the enzyme complex work together, ensuring efficient fatty acid production." Clarification: Fatty acid synthase, a multi functional enzyme complex, plays a central role in fatty acid synthesis. Its individual activities work in harmony within the complex, allowing for the sequential addition of carbon units and the creation of fatty acids up to 16 carbons in length.

very precise, for a person with basic knowledge it is very helpful although I think it could be a bit difficult to understand for someone who does not know anything about these issues.

Love this lecture. Dr. Ahern explains much better than my professor.

I love lecturio, it's the best app in the world. Lecturio has everything you want and can help you to be the best in your class and also be the doctor you want. Lecturio is an opportunity that can give you the change of your student life.

My professors at university failed to explain lipid metabolism in an understandable manner. Prof Ahern does a great job in explaining complex topics and I am really grateful for that. Thank you

Very high-yield. Thank you for underlining this moment, crucial in treating hypercholesterolemia.

Very eloquent :) my favorite on this website! would definitely recommend.

Yea, these lessons site wide need more quiz questions. Only thing holding this site back from being outstanding.

Wonderful! An awesome lecturer, he just has a unique way of passing the message. Great work Sir

Great lecturer very knowledgeable of subject matter at an admirable pace. Good job

I finally understood why keto diet is so effective :) Thank you Dr. Kevin!

The Good: Lecture: 5/5 Amazing Lecture! I learned a lot! The Not so good: Quiz:2/5 Only 1 question....and was not as specific as I would like it to have been. Perhaps consider having at least 50% of the terms discussed included in the Quiz.

Kevin must be the best teacher ever. He explains with a certainty only a person with many years of lecturing can. Simple, easy and fast, making complicated matters seem easy to learn. Compared to the slides i have in med. school, the content is the same. But this guy also gives the explaination in the same amount of time! His body language is also nice to watch as they are firm and open, kind of directing your thoughts, like a maestro. You just have to remember and do some repetition of EVERY detail he mentiones, it will for sure be on the exam. I also use his lectures to simplify my understandings from pdf files from school and heavy textbooks. I will recommend everyone to use this!! Also i love the quiz afterwards. 1rst year university medicine

Easy to understand with the structure of the molecule. Very clear and straight forward.

Very helpful Keep it up .. easy to understand . Lecture in a simple way