Leishmania Braziliensis

by Vincent Racaniello, PhD

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    00:00 So that's cutaneous leishmaniasis. Now leishmania braziliensis causes what's called muco-cutaneous leishmaniasis and the lifecycle is for the most part, very similar. A mosquito has picked up the amastigote form, the amastigote transforms into a flagellated form in the gut of the mosquito, it then moves to the salivary gland, the mosquito, sorry I am saying mosquito but I mean sandfly of course, the sandfly then bites another host, a lesion forms at the site of the bite through the same mechanisms that we've discussed. But for L. braziliensis, the infected macrophages, containing amastigotes, then leave the site of the initial bite and move to muco-cutaneous membranes, either in the oropharynx, or in the genital tract and those two are diagrammed at the bottom of the picture. There, additional tissue destruction occurs, forming the muco-cutaneous lesion and these can be quite horrific. Here's a photograph of a gentleman whose nose has been eroded away by this kind of replication and tissue destruction within macrophages. That's a muco-cutaneous lesion. This can occur in the mouth or in the genital areas, so you can imagine if you simply search for this condition online, you will find horrific photos of people who have amazingly degenerated muco-cutaneous lesions like this one.

    01:42 So that's leishmania braziliensis. Then we have visceral leishmaniasis, which is the

    About the Lecture

    The lecture Leishmania Braziliensis by Vincent Racaniello, PhD is from the course Parasites.

    Included Quiz Questions

    1. Salivary gland
    2. Thorax
    3. Proboscis
    4. GI tract
    5. Palpi
    1. Muco-cutaneous membranes
    2. Basement membranes
    3. Pleural membrane
    4. Epidermis
    5. Hypodermis

    Author of lecture Leishmania Braziliensis

     Vincent Racaniello, PhD

    Vincent Racaniello, PhD

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