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Kidney Disorders: RPGN, Goodpasture Syndrome, SLE & ANCA

by Carlo Raj, MD
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    About the Lecture

    The lecture Kidney Disorders: RPGN, Goodpasture Syndrome, SLE & ANCA by Carlo Raj, MD is from the course Glomerulonephritis. It contains the following chapters:

    • Rapidly Progressive Crescentic Glomerulonephritis
    • Rapidly Progressive Glomerulonephritis (RPGN) & Subtypes
    • Goodpasture's Syndrome
    • SLE Related Kidney Disease
    • ANCA Associated Vasculitis

    Included Quiz Questions

    1. Progression to acute renal failure in 4-12 weeks
    2. Proliferation of visceral epithelial cells
    3. Tubular dysfunction
    4. Chronic renal failure
    5. Clinical syndrome that must be primary type of glomerular disease
    1. Parietal epithelial cell
    2. Visceral epithelial cell
    3. Fenestrated cells
    4. Endothelial cell
    5. Mesangial cell
    1. Minimal Change disease
    2. Post-streptococcal glomerulonephritis
    3. Goodpasture’s
    4. Granulomatosis with polyangiitis
    5. IgA nephropathy
    1. It represents anti-GBM disease.
    2. It presents with granular deposits on immunofluorescence.
    3. It most commonly affects the elderly.
    4. It may be diagnosed using electron microscopy.
    5. It involves IgM deposition on the GBM.
    1. Fibrin crescents with H&E stain on light microscopy
    2. Negative findings on immunofluorescence
    3. Polyuria
    4. Proteinuria > 3.5 g/day
    5. Lack of RBC casts in the urine
    1. Henoch-Schonlein Purpura associated type 2 RPGN involves IgM complex deposits.
    2. SLE-associated type 2 RPGN involves subendothelial deposits.
    3. All of the answers are correct.
    4. Type 2 RPGN involves deposition of preformed immune complexes.
    5. Infectious etiologies for type 2 RPGN usually involve subepithelial deposits.
    1. Anti-myeloperoxidase
    2. Anti-proteinase 3
    3. Anti-dsDNA
    4. Anti-saccharomyces cerevisiae
    5. Cytoplasmic antineutrophil cytoplasmic antibodies
    1. HLA-BR2
    2. HLA- B27
    3. HLA-DQ8
    4. HLA-B47
    5. HLA-DR3
    1. Sinusitis
    2. Hemoptysis
    3. Pneumonitis
    4. Acute renal failure
    5. Hematuria
    1. NSAIDs
    2. Plasma exchange
    3. Renal transplantation
    4. Cyclophosphamides
    5. Corticosteroids
    1. Immune complex deposition is subendothelial.
    2. It is classified as the membranous form of glomerulonephritis.
    3. It has a linear pattern on immunofluorescence.
    4. It presents with a spike and dome appearance on light microscopy.
    5. It presents with nephrotic syndrome features.
    1. 10%
    2. 85%
    3. 50%
    4. 1%
    5. 20%
    1. Migratory arthalgias
    2. Abdominal pain
    3. Palpable purpura
    4. Intestinal bleeding
    5. Vomiting
    1. Goodpasture’s syndrome
    2. Polyarteritis nodosa
    3. All answers are correct.
    4. Microscopic angiitis
    5. Churg-strauss
    1. Saddle nose
    2. Hypertension
    3. Cough
    4. Hemoptysis
    5. Hematuria
    1. Elevated serum IgE
    2. Positive c-ANCA
    3. Decreased serum complement levels
    4. Hyponatremia
    5. Hypoalbuminemia

    Author of lecture Kidney Disorders: RPGN, Goodpasture Syndrome, SLE & ANCA

     Carlo Raj, MD

    Carlo Raj, MD


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    Good summary
    By Hamed S. on 07. March 2017 for Kidney Disorders: RPGN, Goodpasture Syndrome, SLE & ANCA

    Found the explanations clear and to the point. I've always struggled with GN and I think I'm slowly begin to appreciate this topic