Investigation and diagnosis of blood disorders

by Paul Moss, PhD

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    Hello, In this lecture, I would like to concentrate on investigation and diagnosis of the blood system. Learning outcomes of this lecture will include the fact that a diagnosis is made by combining the history, examination and investigation. Blood count, blood film and blood clotting are basic investigations used in many patients with hematological disorders, but sometimes a bone marrow may be required. Genetic analysis is now essential in many cases for the diagnosis of hematological disorders. And finally a range of additional specialized tests may be needed and that can often include imaging such as x-rays. Now the clinical approach to the diagnosis in the patient with blood disorders involves three major approaches. This is true for any clinical condition, diagnosing an infection, rheumatoid arthritis, its always the same. Firstly take a medical history, listen to the patient and listen to the symptoms they describe. Secondly, perform an examination. And finally, if necessary use of investigations. and in this lecture, we will be largely focusing on those investigations and their appropriate use within the management of patients with haematological disorders. Let's just spend a minute talking about taking a history in a patient with a blood disorder. Of course there's all sorts of things that one might need to ask and the patient may tell you. If it is a red cell problem, that will usually mean anaemia, in which patient will be fatigued, or short of breath because they are not getting enough oxygen to their tissues. If it is a problem with white cells, that might lead to unusual or prolonged infections. Whereas excess white cells, too many cells can happen in malignant diseases such as leukaemia and lymphoma. The patients may notice swellings or lumps. Finally, anything that affects platelet function can lead to bruising and...

    About the Lecture

    The lecture Investigation and diagnosis of blood disorders by Paul Moss, PhD is from the course Hematology: Basics. It contains the following chapters:

    • Patient with a Blood Disorder
    • Investigation of the Blood System
    • Additional Investigations

    Included Quiz Questions

    1. Neutrophilia
    2. Neutrocytosis
    3. Neutropenia
    4. Lymphopenia
    5. Leucopenia
    1. Haemoglobin 140g/L; White cells 6x109/L; Platelets 375x109/L
    2. Haemoglobin 120g/L; White cells 6x109/L; Platelets 375x109/L
    3. Haemoglobin 140g/L; White cells 3x109/L; Platelets 375x109/L
    4. Haemoglobin 120g/L; White cells 6x109/L; Platelets 125x109/L
    5. Haemoglobin 185g/L; White cells 6x109/L; Platelets 150x109/L
    1. ultrasound
    2. PET
    3. CT scan
    4. Radionucleotide imaging
    5. MRI scan

    Author of lecture Investigation and diagnosis of blood disorders

     Paul Moss, PhD

    Paul Moss, PhD

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