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Inflammatory Signalling and Inflammasomes

by Peter Delves, PhD
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      Slides Innate Immune System.pdf
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    About the Lecture

    The lecture Inflammatory Signalling and Inflammasomes by Peter Delves, PhD is from the course Innate Immune System. It contains the following chapters:

    • Signaling from Cell Surface PRR
    • Generation of the Inflammasome

    Included Quiz Questions

    1. IKK
    2. MyD88
    3. NFkB
    4. IkB
    5. ASC
    1. IKK upregulated- gene transcribed by NFkB upregulated
    2. IKK upregulated- IkB would more effectively inhibit NFkB
    3. IKK downregulated- gene transcribed by NFkB upregulated
    4. IKK downregulated- increased IkB phosphorylation
    5. IKK upregulated- kinase activity decreases
    1. Pro-caspase-1 activated to active caspase-1 which converts Pro-IL-1ß and Pro-IL-18 activated to IL-1ß and IL-18
    2. Pro-caspase-1 activated to pro-caspase-2 which converts Pro-IL-1ß and Pro-IL-18 to IL-1ß and IL-18
    3. Pro-caspase-1 activated to active caspase-1 which converts IL-1ß and IL-18 to Pro-IL-1ß and Pro-IL-18
    4. Caspase-1 activated to Pro-caspase-1 which converts IL-1ß and IL-18 to Pro-IL-1ß and Pro-IL-18
    5. Pro-caspase-1 activated to active caspase-1 which converts IL-1ß to IL-18
    1. Activate pro-inflammatory cytokines to be released from the cell, increasing inflammation
    2. Inhibit pro-inflammatory cytokines to decrease inflammation
    3. Produce pro-inflammatory cytokines using transcription factors
    4. Store pro-inflammatory cytokines to be released when pathogens are encountered
    5. Inactivate inflammatory response by downregulating inflammatory cytokines

    Author of lecture Inflammatory Signalling and Inflammasomes

     Peter Delves, PhD

    Peter Delves, PhD


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