HER2 Receptor and Bcr-Abl
About the Lecture
The lecture HER2 Receptor and Bcr-Abl by Kevin Ahern, PhD is from the course Hormones and Signal Transduction. It contains the following chapters:
- HER2 Receptor
- Other Mutations – Bcr-Abl
Included Quiz Questions
Which statement regarding the HER2 receptor is true?
- It is inhibited by trastuzumab/herceptin.
- It is an intracellular receptor.
- It promotes apoptosis in malignant cells.
- It is never expressed in malignant cells.
Which statement regarding the Bcr-Abl fusion protein is true?
- It creates a tyrosine kinase that is inhibited by imatinib.
- It is a tyrosine kinase that is activated by translocation between chromosomes 11 and 22.
- It is treated with imatinib, a GTPase inhibitor.
- It is caused by a translocation between chromosomes 15 and 19.
Which chromosome carries the Philadelphia translocation, and how is it formed?
- It is carried on chromosome 22 and formed by the reciprocal translocation of genetic material between chromosome 9 and chromosome 22.
- It is carried on chromosome 9 and formed by the reciprocal translocation of genetic material between chromosome 9 and chromosome 22.
- It is carried on chromosome 19 and is formed by the reciprocal translocation of genetic material between chromosome 19 and chromosome 22.
- It is carried on chromosome 22 and is formed by the reciprocal translocation of genetic material between chromosome 6 and chromosome 22.
- It is carried on chromosome 6 and is formed by the reciprocal translocation of genetic material between chromosome 6 and chromosome 22.
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Author of lecture HER2 Receptor and Bcr-Abl
Kevin Ahern, PhD
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Was very clear just speak very quickly, then I have to repeat the lesson to understand complete anyway its not important, I would like just when speaking about the oncogenes give some examples about the food that causes
