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Hepatitis D & E
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Slides GD liver disease.pdf
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00:01 A few words about hepatitis D, now. 00:03 The major ones are A, B, and C. 00:05 Just a few words about D & E. 00:08 Just to make sure we're complete and you don't miss any questions. 00:11 Hepatitis D, right off the bat- the most important identification of this will be. 00:16 It's a partial RNA. 00:18 And, With that said, it will never cause fulminant hepatitis by itself. 00:24 It can't - partial. It requires the help. Almost always with the partner, it's partner is b. 00:31 concomitant infection Can co-infect or super infect with HPV and that becomes ridiculously dangerous. 00:38 It accelerates the liver damage like you would not believe. 00:41 Frequent, especially among, remember, Hepatitis B, how would you pass this on? Sexually or parentally, IV drug abusers are key candidates that you are paying attention to. 00:55 Diagnosis: Anti-HDV Ab. 00:59 Empiric therapy with, once again, IFN stands for interferon; recommended due to increased risk of liver disease. 01:06 Fulminant liver disease remember. 01:08 Remember, often times, d & b will be coming together as a package. 01:12 Keep that in mind partial, DNA. 01:15 Few words about hepatitis E here. 01:18 This is an RNA virus. 01:20 This is through the feco-oral route. 01:22 What is the other type of virus that is also commonly feco oral? Good. Hepatitis A. 01:29 Endemic areas you definitely want to know. 01:31 This include the Indian sub-continent and Mexico, and Southeast Asia. 01:39 Clinically resembles very much feco-oral. 01:43 HAV infection. 01:44 High mortality in pregnancy is big time for you. 01:48 High mortality in pregnancy from Fulminant liver failure up to 20%. 01:52 That is unfortunate. 01:53 That is not a small percentage. 01:55 So, if you think about hepatitis e, reflexively, you should be thinking about, The Far East Area, South East Asia, maybe Indian sub continent or the Mexican peninsula. 02:08 And then you should be thinking about high mortality in pregnancy. 02:12 Diagnosis: suspect with history to travel to such endemic areas. 02:17 And HEV-IgM Available through your CDC.
About the Lecture
The lecture Hepatitis D & E by Carlo Raj, MD is from the course Liver Diseases: Basic Principles with Carlo Raj.
Included Quiz Questions
What type of virus is hepatitis D?
- Partial RNA virus
- ssDNA virus
- Partial DNA virus
- RT cDNA virus
- DNA virus
Which of the following populations is MOST at risk for developing a hepatitis E infection?
- Poor sanitation
- IV drug abusers
- Homosexual men
- Pregnant women
- Persons with hemophilia
How does the phenomenon of superinfection occur with hepatitis B and hepatitis D?
- Both viruses affect 1 cell and cause worsening of the infection.
- Both viruses affect the cell, with the net effect being impairment of the cell function similar to that of a cell affected by 1 virus.
- Both viruses affect 1 cell, with the net effect being attenuation of cell function.
- First, the hepatitis B virus affects the cell, and then hepatitis D decreases the destruction caused by hepatitis B on the cell.
- The hepatitis D virus functions independently of the hepatitis B virus.
Which of the following is NOT an endemic area for hepatitis E virus?
- Northern South America
- Southeast Asia
- Mexico
- Indian subcontinent
- African subcontinent
Author of lecture Hepatitis D & E
Carlo Raj, MD
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