Other haemopoietic malignancies and aplastic anemia

by Paul Moss, PhD

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    Hello, In other lectures, we focused on leukaemia and lymphoma, but now I want to focus on other haemopoietic malignancies and aplastic anaemia. We will learn in this lecture, the myelodysplasia and myeloproliferative disease are clonal disorders of the myeloid lineage within the bone marrow. Myeloma is a malignant disorder of plasma cells and is treated with a wide range of novel therapies. And finally aplastic anaemia results in the loss of stem cells in the bone marrow and may result from an autoimmune process. Let us start with myelodysplasia, break the word down myeloid bone marrow, dysplasia dysplastic or deficient function of the bone marrow. This is a group of disorders, which are clonally derived of a haemopoietic stem cell and they are characterized by bone marrow failure in association with dysplastic features in one or more cell lineages. What do I mean by that? What does dysplastic mean? It means that the cells when we look at them at the microscope display abnormal features. Let me show you by moving to the right-hand side of the screen, you will see three figures there. On the top left, believe it or not, these are neutrophils, but they do not look like normal neutrophils, I hope you agree. They are hypergranule. We do not see the granules that you see in the normal neutrophil and they are also not so heavily lobed, just two lobes. So these are dysfunctional neutrophils. On the top right an unusual cell is a megakaryocyte in the bone marrow, but again very abnormal looking not enough nuclei much small of the normal of the very prominent cytoplasm. And at the bottom, that is a special stain for iron in erythroblasts in the bone marrow and you will see around the red nucleus ring of iron...

    About the Lecture

    The lecture Other haemopoietic malignancies and aplastic anemia by Paul Moss, PhD is from the course Hematology: Advanced. It contains the following chapters:

    • Myelodysplasia
    • Myeloproliferative Disease
    • Aplastic Anaemia

    Included Quiz Questions

    1. Lymphoblasts
    2. Hypogranular neutrophils
    3. Megakaryocytes with reduced number of nuclei
    4. Reduction in the number of nuclear lobes in neutrophils
    5. Ring sideroblasts
    1. Hb 14, WBC 9, platelets 700
    2. Hb 8, WBC 8, platelets 1000
    3. Hb 19, WBV 10, platelets 620
    4. Hb 8, WBC 8, platelets 400
    5. Hb 14, WBC 9, platelets 300
    1. Fanconi anaemia
    2. Cytic fibrosis
    3. Thalassaemia
    4. Sickle cell anaemia
    5. Muscular dystrophy

    Author of lecture Other haemopoietic malignancies and aplastic anemia

     Paul Moss, PhD

    Paul Moss, PhD

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