00:02
Now what does glucagon do?
The functions of glucagon
are primarily it's break down
glycogen.
00:11
So there's a lot of glycogen
stored in places like the liver.
00:14
And this is one of the
stimuli to have it break down.
00:18
It's done by activating
the enzymes which break down
glycogen and inhibiting the
enzymes that form new glycogen.
00:30
The last thing that it does is
stimulates the enzymes which do
the final break down product
going from glucose 6-phosphate
to glucose.
00:42
Then the glucose is transported
out of the cell to transporter.
00:49
Now that is the process
of breaking down glycogen,
releasing glycogen out
in the circulation.
00:56
So this should remind you
of the process of --we're not
building things here
with glucagon.
01:02
We're breaking down glycogen so
we can use that blood glucose.
01:07
What else does it stimulate.
01:10
The enzymes associated
with gluconeogenesis.
01:13
So gluconeogenesis is
the process
of making new glucose out of things that weren't glucose
to start with like
amino acids.
01:24
It also stimulates the enzymes
associated with lipolysis.
01:27
So there you have fat.
01:30
You can break it down into more
simple form and release free
fatty acids into
the circulation.
01:36
And finally it stimulates
ketogenesis
which is the formation
of ketone bodies.
01:42
So between all four
of these processes,
you should think of --okay,
we're breaking down glycogen
so that we can get
more blood glucose.
01:51
We're making new blood glucose.
01:53
We're breaking down fats.
01:54
So the free fatty acids
are in the circulation.
01:57
And we're forming ketone bodies.
01:59
All of those can be used as
energy substrates for different
tissues of the body.
02:05
So glucagon is really preparing
you so make sure you can
use energy that's been
stored in the body.
02:13
So you can use it for
increase in metabolism.
02:18
So let's now look at this in
more of a systemic effect.
02:22
The systemic view always
let's us take a step back,
point to the various tissues,
see where the different
molecules are going.
02:31
And as you're studying
for your test,
this is a very
important thing to do,
it's easy to get lost in the
leaves of a tree without taking
a step back to look at the
branches and how their shape is.
02:43
So that is this
kind of a process.
02:45
So we know we have the
release of blood glucose.
02:50
Usually comes from the liver by
breaking down glycogen through
a number of steps and then
finally releasing blood glucose.
03:01
Fatty acids are also broken down
through lipolysis
and moved out of adipose tissue
into the circulation.
03:11
Those fatty acids are also
form the basis of backdrop
for ketoacids.
03:19
So here we've got
increases in glucose,
fatty acids and ketoacids.
03:25
All help us do what,
increase our metabolism.
03:30
Because we're responding to some
sort of stressful environment.