00:01
Let’s move on to
choriocarcinoma.
00:03
It’s a malignant neoplasm
of trophoblastic cells.
00:06
It can be preceded by
hydatidiform mole,
50% of the time, which one?
Complete or partial, please?
Use the C’s.
00:15
A complete mole may go on to
greater risk of choriocarcinoma.
00:19
Before we move on though,
I very much wish to remind you
that you can have
gestational choriocarcinoma
and don’t get this confused.
00:28
Once again reinforce this,
so clearly you are going
to organize your thoughts.
00:33
Gestational choriocarcinoma,
non-gestational choriocarcinoma.
00:37
So when you say non-gestational
choriocarcinoma,
what organ are you then
affecting in a male or female?
Gonads.
00:45
Gonads.
00:46
Remember when we talked
about germ cell tumors
and your gonadal tumors
of a male or female.
00:51
Well, choriocarcinoma
can be part of that.
00:54
It’s non-gestational.
00:55
Here, however, gestational.
00:58
What else?
Abortion of ectopic,
possibility of going
onto choriocarcinoma.
01:03
Even normal term pregnancy
has a risk of 30%.
01:08
Not impossible to
monitor development
of trophoblastic disease because
you’re actually monitoring the hCG.
01:14
So the more that you have
proliferation of your trophoblast,
you’d find there to be a
correlation with beta-hCG.
01:22
Unfortunately, with
choriocarcinoma, it’s early.
01:25
Remember, this is a cancer
and this is carcinoma that
likes to go through the blood.
01:30
So there will be early
hematogenous spread.
01:33
And it’s responsive to
chemotherapy, thank goodness.