Anti-HIV Agents: Fusion Inhibitors – Antiviral Drugs

by Pravin Shukle, MD

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    00:00 Let's start off with the Anti-HIV agents.

    00:04 Anti-HIV agents are divided up into several categories.

    00:08 The fusion inhibitors.

    00:10 The reverse transcriptase inhibitors.

    00:12 The strand transfer inhibitors.

    00:14 Protease inhibitors and the CCR5 Antagonist.

    00:18 Now the reverse transcriptase inhibitors are divided into the Neucloside Reverse Transcriptase Inhibitors and the Non-Neucloside Reverse Transcriptase Inhibitors.

    00:30 Let's start off with the fusion inhibitors.

    00:32 Now remember that fusion inhibitors are blocking the viral attachment and entry portion of the cells cycle or the viral cycle.

    00:41 There are many out there on the market.

    00:44 They are exceedingly expensive.

    00:46 Some of them run up to $25, 000 a year.

    00:50 Because of the very high price they are little used in clinical practice but they are quite effective.

    00:56 They disrupt the molecular machinery at the final stage of fusion with a target cell.

    01:01 And this prevents the uneffected cells from being infected going forward.

    01:06 The adverse events are really mostly limited to injection site reactions.

    01:11 And some patients will also complain of a cough or maybe a shortness of breath.

    01:15 Or sometimes joint pains.

    01:17 And we think that this an immune-mediated issue.

    About the Lecture

    The lecture Anti-HIV Agents: Fusion Inhibitors – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Included Quiz Questions

    1. Price
    2. Adverse reactions
    3. Bioavailability
    4. Drug interactions
    5. Resistance
    1. Injection site reaction
    2. Bone marrow suppression
    3. Hepatomegaly
    4. Pancreatitis
    5. Anemia

    Author of lecture Anti-HIV Agents: Fusion Inhibitors – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD

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