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Macrocytic Anemia: Vitamin B12 and Folate Deficiency – Red Blood Cell Pathology

by Carlo Raj, MD
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    About the Lecture

    The lecture Macrocytic Anemia: Vitamin B12 and Folate Deficiency – Red Blood Cell Pathology by Carlo Raj, MD is from the course Macrocytic Anemia – Red Blood Cell Pathology (RBC). It contains the following chapters:

    • Etiology of Macrocytic Anemias
    • Other Megaloblastic Anemias
    • Causes of Megaloblastic Anemias
    • Vitamin B12 Deficiency
    • Vitamin B12 Metabolism
    • Folate Deficiency
    • Clinical Pathology of Macrocytic Anemias

    Included Quiz Questions

    1. Pancytopenia
    2. Increased DNA synthesis
    3. Leukocytosis
    4. Erythrocytosis
    5. Reduced number of blasts
    1. Increased erythropoiesis
    2. Reduced pyrimidine synthesis
    3. Reduced DNA synthesis
    4. MCV>100
    5. Pancytopenia
    1. UMP synthase
    2. Thymidylate synthase
    3. PRPP synthase
    4. Dihydrofolate reductase
    5. Ribonucleotide reductase
    1. Hyperammonemia
    2. Hyperglycemia
    3. Hyperphosphatemia
    4. Hyperkalemia
    5. Hypercalcemia
    1. Autosomal recessive
    2. Autosomal dominant
    3. Chromosomal inheritance
    4. X-linked dominant
    5. X-linked recessive
    1. Hb F
    2. Hb S
    3. Hb H
    4. Hb A2
    5. Hb A
    1. Vitamin B12
    2. Vitamin B6
    3. Ornithine Transcarbamylase
    4. Dihydrofolate
    5. UMP Synthase
    1. Homocysteine to Methionine
    2. Methionine to Homocysteine
    3. Tetrahydrofolate to Dihydrofolate
    4. Dihydrofolate to Tetrahydrofolate
    5. dUMP to dTMP
    1. Increased homocysteine level in the blood
    2. Decreased homocysteine level in the blood
    3. Increased level of methylmalonic acid in the blood
    4. Increased level of methylmalonic acid in the urine
    5. Decreased homocysteine level in the urine
    1. Dihydrofolate reductase
    2. Thymidylate synthase
    3. PRPP synthase
    4. Ribonucleotide reductase
    5. UMP synthase
    1. Folinic acid
    2. Ascorbic acid
    3. Folic acid
    4. Vitamin B12
    5. Retinoic acid
    1. Thymidylate synthase
    2. Dihydrofolate reductase
    3. PRPP synthase
    4. Ribonucleotide reductase
    5. UMP synthase
    1. Dorsal column
    2. Lissauer’s tract
    3. Spinocerebellar tract
    4. Corticospinal tract
    5. Anterolateral tract
    1. Replacement of Acetyl CoA with Propionyl-CoA
    2. Replacement of Propionyl-CoA with Acetyl CoA
    3. Increased blood levels of succinyl-CoA
    4. Increased blood levels of methylmalonic acid
    5. Increased blood levels of homocysteine
    1. Parietal cells
    2. S cells
    3. K cells
    4. I cells
    5. Chief cells
    1. Intrinsic factor
    2. Somatostatin
    3. Secretin
    4. Cholecystokinin
    5. R binder protein
    1. Terminal ileum
    2. Jejunum
    3. Pylorus
    4. Antrum
    5. Duodenum
    1. Diphyllobothrium latum
    2. Clonorchis Sinensis
    3. Necator americanus
    4. Echinococcus granulosus
    5. Schistosoma mansoni
    1. Pernicious anemia
    2. Crohn’s disease
    3. Malnutrition
    4. Alcoholism
    5. Chronic pancreatitis
    1. Pepsin
    2. Pepsinogen
    3. Trypsin
    4. Cholecystokinin
    5. Somatostatin
    1. Pancreatic enzymes
    2. Small intestinal secretions
    3. Bile acids
    4. Gastric secretions
    5. Liver enzymes
    1. Terminal ileum
    2. Duodenum
    3. Antrum
    4. Ileum
    5. Jejunum
    1. Dietary deficiency
    2. Celiac disease
    3. Drugs
    4. Malabsorption syndrome
    5. Pregnancy
    1. Intestinal conjugase in jejunum
    2. Intestinal conjugase in ileum
    3. Intestinal conjugase in duodenum
    4. Secretin in Stomach
    5. Cholecystokinins in duodenum
    1. Methylmalonic aciduria in vitamin B 12 deficiency
    2. None of these
    3. Homocysteinuria in vitamin B 12 deficiency
    4. Homocysteinuria in folic acid deficiency
    5. Methylmalonic aciduria in folic acid deficiency
    1. Lateral corticospinal tract
    2. Anterior horn
    3. Dorsal column
    4. Anterolateral tract
    5. Lateral horn
    1. Intrinsic factor
    2. R binder protein
    3. Folinic acid
    4. Folic acid
    5. Vitamin B 12
    1. Hypersegmented neutrophil
    2. Hypersegmented eosinophil
    3. None of these
    4. MCV > 100
    5. Macrocytosis

    Author of lecture Macrocytic Anemia: Vitamin B12 and Folate Deficiency – Red Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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