Escherichia Coli (EPEC)

by Vincent Racaniello, PhD

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    00:01 Alright, so that's traveler's diarrhea caused by ETEC E. coli. Let's look at another type of E. coli; these are enteropathogenic E. coli or EPEC. Hard to remember ETEC, EPEC now, enteropathogenic. These also cause watery diarrhea, but these bacteria are slightly different, they do not have fimbriae to attach. They have other things. They have no ST and they have no LT toxins. Remember those were two toxins produced by the ETEC strains which are important for causing the watery diarrhea, but the EPEC strains of E. coli do not produce those toxins. So how do they produce diarrhea? These EPEC strains of E. coli adhere to the intestinal cells via two proteins, one is shown as a helical protein in the first panel of the illustration and the second is via an intimin adhesin, which is the small blue box, and these cause the bacteria to adhere very tightly to the epithelial surface and we think that binding changes the surface and that causes the diarrhea, we call this adhesion and effacement and it's a deformation of the villi caused by bacterial attachment and that causes diarrhea, not the elaboration of toxins, as with the ETEC strains. Alright so those are enteropathogenic E. coli.

    About the Lecture

    The lecture Escherichia Coli (EPEC) by Vincent Racaniello, PhD is from the course Bacteria.

    Included Quiz Questions

    1. Intimin
    2. LT toxin
    3. ST toxin
    4. Shiga-like toxin
    5. Pili

    Author of lecture Escherichia Coli (EPEC)

     Vincent Racaniello, PhD

    Vincent Racaniello, PhD

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