Lectures

DPP-4 Inhibitors and GLP-1 Analogues – Diabetes Medications

by Pravin Shukle, MD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides DiabetesMedications EndocrinePharmacology.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    Let's move on to incretin based therapies. Now before I talk about the actual drugs, I want to talk about what incretins are. So let's imagine you have an orange, and you decide to eat it, and it goes into your stomach. Well your stomach and your small bowel will release something called incretins. These incretins act on the pancreas in two ways, not one way but two ways. First, it will act on the beta cells to actually increase the amount of insulin that you release into the body. This decreases sugar levels. The other action is that it works on alpha cells, to decrease glucagon secretion and once again decrease sugar levels. Now this is an important distinction between these drugs and other drugs. Because the amount of alpha activity with the incretins is much greater than the other medications or the other hormones. A DPP4 is kind of like pacman because it goes in and eats the incretins. So it's kind of our built in mechanism to get rid of incretins once we no longer need them. A DPP4 inhibitor, gets rid of pacman, right. So DPP4 inhibitor now allows more incretins to do its job for a longer time. So there is a couple of advantages to this particular method. First, it's a very natural way of affecting your systems because you're taking advantage of internal systems to bring down the sugar, rather than say artificially stimulating a cell to secrete insulin. You're using incretins which are a naturally produced hormone and you're letting them do their job for a longer time. The other advantages that the DPP4 inhibitors almost have no hypoglycemic risk. Now a GLP-1 analogue is an analogue of incretin. So, DPP4 inhibitors and GLP-1 analogues are working through the incretin pathway. They...

    About the Lecture

    The lecture DPP-4 Inhibitors and GLP-1 Analogues – Diabetes Medications by Pravin Shukle, MD is from the course Endocrine Pharmacology. It contains the following chapters:

    • DPP4-I's and GLP-1 Analogues
    • DPP4-I's and GLP-1 Analogues – Adverse Events

    Included Quiz Questions

    1. Acts of the pancreas to reduce blood sugar.
    2. Acts on the kidney to reduce blood sugar.
    3. Acts on the small bowel to reduce blood sugar.
    4. Acts on the pancreas to increase blood sugar.
    5. Acts on the pancreas to increase blood lipase levels.
    1. DPP-4 inhibitors act on DPP-4 to increase levels of incretins GLP-1 analogues acts as an analogue of incretin
    2. GLP-1 analogues are pills DPP-4 inhibitors are injections
    3. GLP-1 analogues increase risk of pneumonitis DPP-4 inhibitors increase risk of GI upset
    4. GLP-1 analogues decreases HbA1c by a greater amount than DPP-4 inhibitors
    5. GLP-1 analogues act on DPP-4 to increase levels of incretins DPP-4 inhibitors acts as an analogue of incretin

    Author of lecture DPP-4 Inhibitors and GLP-1 Analogues – Diabetes Medications

     Pravin Shukle, MD

    Pravin Shukle, MD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0