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Distal Convoluted Tubule (DCT): Pathophysiology

by Carlo Raj, MD
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    About the Lecture

    The lecture Distal Convoluted Tubule (DCT): Pathophysiology by Carlo Raj, MD is from the course Diseases of the Nephron. It contains the following chapters:

    • Tubular Transport
    • Bartter and Gitelman Syndrome
    • Antenatal Bartter Syndrome
    • Gitelman Syndrome

    Included Quiz Questions

    1. Urine that is hypotonic to plasma.
    2. Urine that is hypertonic to plasma.
    3. Urine with an osmolarity of 600 mOsm/L.
    4. Urine with an osmolarity of 300 mOsm/L.
    5. Urine that is isosmotic to plasma.
    1. Thick Ascending limb of the loop of Henle
    2. Collecting Duct
    3. Thin Ascending limb of the loop of Henle
    4. Distal convoluted tubule
    5. Descending limb of the loop of Henle
    1. Renal outer medullary potassium channel
    2. Epithelial Na channel
    3. Na/H exchanger
    4. Aquaporins
    5. Thiazide sensitive NaCl cotransporter
    1. It is the beginning of the diluting segment.
    2. Fluid in the lumen of this segment is hypertonic
    3. It is not necessary for countercurrent mechanism maintenance.
    4. It contains mostly obligated water.
    5. It is permeable to water.
    1. Na reabsorption in the distal convoluted tubule is inhibited by furosemide.
    2. Na reabsorption is increased by the action of aldosterone.
    3. 5% of Na is reabsorbed in the distal convoluted tubule along with Cl.
    4. 25% of Na is reabsorbed in the thick ascending limb along with K and Cl.
    5. 65% of Na is reabsorbed isotonically in the proximal convoluted tubule.
    1. Metabolic alkalosis
    2. Anion gap metabolic acidosis
    3. Respiratory acidosis
    4. Respiratory alkalosis
    5. Non-anion gap metabolic acidosis
    1. Hypotension
    2. Fatigue
    3. Cardiac arrhythmia
    4. Ileus
    5. Muscle weakness
    1. Inhibition of NaCl symport
    2. Inhibition of NaK2Cl symport
    3. Inhibition of ROMK channel
    4. Inhibition of Na/H+ exchanger
    5. Inhibition of isotonic fluid reabsorption
    1. NaK2Cl cotransport
    2. NaCl symporter
    3. Na-Ca exchanger
    4. Epithelial Na Channel
    5. Outer medullary potassium backleak channel
    1. Potassium
    2. Sodium
    3. Calcium
    4. Magnesium
    5. Chloride
    1. Hypocalciuria
    2. Secondary hyperaldosteronism.
    3. Hypomagnesemia
    4. Metabolic alkalosis
    5. Hypokalemia
    1. Furosemide
    2. Indomethacin
    3. Amiloride
    4. Spironolactone
    5. ACE inhibitors
    1. Inhibit prostaglandin
    2. Reduce inflammation
    3. Decrease filtration fraction
    4. Fever reduction
    5. Analgesia
    1. Thick ascending limb of the loop of Henle
    2. Distal convoluted tubule
    3. Descending limb of the loop of Henle
    4. Proximal convoluted tubule
    5. Collecting duct
    1. Nocturia
    2. Mental retardation
    3. Hyperventilation
    4. Hypertension
    5. Sensorineural deafness
    1. Magnesium
    2. Hydrogen
    3. Potassium
    4. Calcium
    5. Sodium
    1. Hypocalciuria
    2. Hypomagnesemia
    3. Hyperprostaglandinemia
    4. Hypokalemia
    5. Hyponatremia
    1. Suppresion of ADH
    2. Loss of isotonic NA reabsorption
    3. Activation of PTH receptors
    4. Aldosterone activation
    5. Inhibition of NaK2Cl cotransport

    Author of lecture Distal Convoluted Tubule (DCT): Pathophysiology

     Carlo Raj, MD

    Carlo Raj, MD


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