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Development of the Pancreas – Liver, Gallbladder and Pancreas Development

by John McLachlan, PhD
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    00:01 The pancreas is an unusually complex pattern of development. It initially appears as a small ventral pancreatic bud, but there is a separate dorsal pancreatic bud also present on the dorsal aspect of the gut. The ventral pancreas is essentially coming from the same source as the gall bladder and cystic duct as part of a diverticulum growing out from the early liver primordium. As the gut rotates and as the stomach rotates, there are significant changes in the arrangement of the organs of the body, now what will happen is that the ventral bud is carried dorsally along with the bile duct itself. Now, as the stomach rotates and the gut rotates with it, so the ventral pancreatic bud swings round until it comes in contact with the dorsal pancreatic bud and there, the two of them will fuse roundabout the six weeks after fertilization. So the two separate components will form a single organ subsequently. Normally, the dorsal bud will give rise to what’s known as the head, the body, and the tail of the pancreas, and the ventral bud will give rise to the uncinate process. Usually however, it’s the ventral bud which gives rise to the definitive duct of the pancreas. However, considerable variation can occur, and it could be the dorsal duct which becomes the main duct, or indeed, both ducts may persist later on into adult life.

    01:33 Here is the same image seen in a larger view. So you can see the replacement of the original duct from the dorsal pancreatic developing structure by the ventral duct. Here we can see the pancreas seen in cross-section, and you can also see that as the stomach rotates during the course of development and the liver is thrown over to the right, so the pancreas also is thrown over to the left-hand side of the body. Now, a number of abnormalities may occur as part of this process.


    About the Lecture

    The lecture Development of the Pancreas – Liver, Gallbladder and Pancreas Development by John McLachlan, PhD is from the course System-Specific Embryology with John McLachlan.


    Author of lecture Development of the Pancreas – Liver, Gallbladder and Pancreas Development

     John McLachlan, PhD

    John McLachlan, PhD


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