Evaluation of the First Non-Febrile Seizure and Childhood Epilepsy

00:01 Evaluation of First Non-Febrile Seizure.

00:04 We have two age groups.

00:06 Children and adults.

00:08 Let’s talk about these seizures.

00:12 H&P in children is important.

00:15 In a child, EEG, lab work, neuroimaging, CSF analysis based on the age of your patient and clinical situation.

00:23 H&P in adult EEG and neuroimaging for the most part is all that you’d require here to find out what’s causing the first non-febrile seizure.

00:35 Laboratory evaluation and CSF analysis is case dependent, whereas in a child, CSF analysis is based on age of patient and then clinical situation.

00:48 Childhood Epilepsy.

00:50 So what are all the different causes of childhood epilepsy? And you keep this separate from febrile at this point.

00:59 Obviously, I need to put it in as well, but...

01:02 febrile seizure, remember the fever itself could be the possible trigger for the – The fever could be the trigger for the seizure.

01:10 Metabolic etiologies includes cerebral folate deficiency, creatine disorders, folinic acis responsive seizures GLUT1 deficiency, mitochondrial disorders, PNPO deficiency and peroxismal disorders.

01:29 Genetic factors of childhood epilepsy.

01:31 Genetic means any genetic mutation that can be chromosomal or molecular that results in the syndrome or epilepsy is a core feature and that is not a metabolic disorder.

01:42 It is important to stick to the accurate ILAE classification in epilepsy.

01:48 Multiple defects in metabolic pathways and other genetic diseases.

01:53 Idiopathic may be perhaps, the genetics could play a role, especially as we learn more and more and more about these channels, right? So you know about channelopathies.

02:05 Meningitis, possibly head injury.

02:08 Perinatal insults such as corticaldysplasia or palsy, perhaps.

02:14 Or tumors, much less common.

02:17 Much less common.

02:18 Childhood epilepsy.

02:20 Unprovoked.

02:21 Could febrile seizure go into epilepsy? Yes, it could.

02:26 But a very small percentage.

02:29 Hopefully, as we’re moving through here, you’re gaining a clear understanding of what you need to know for seizures in general.