Pyrimidine de novo Metabolism: ATCase Reaction
About the Lecture
The lecture Pyrimidine de novo Metabolism: ATCase Reaction by Kevin Ahern, PhD is from the course Purine and Pyrimidine Metabolism.
Included Quiz Questions
The amount of pyrimidine is controlled by which enzyme?
- ATCase
- PRPP synthetase
- PRPP amidotransferase
- IMP dehydrogenase
- Adenylosuccinate synthetase
The ATCase enzyme is activated due to an excess of which of the following?
- ATP and aspartate
- CTP and aspartate
- GTP and aspartate
- UTP and aspartate
- TTP and aspartate
How do the higher concentrations of CTP affect the production of pyrimidine?
- The higher concentrations of CTP inhibit the ATCase enzyme and therefore stop the further synthesis of pyrimidine nucleotides.
- The higher concentrations of CTP inhibit the ATCase enzyme via a feedback mechanism and hence stop the further synthesis of purine nucleotides.
- The higher concentrations of CTP activate the ATCase enzyme, and hence synthesis of pyrimidine nucleotides is enhanced.
- The higher CTP concentrations activate the ATCase enzyme, and hence synthesis of purine nucleotides is enhanced.
- The higher CTP concentrations activate the ATCase enzyme, and hence synthesis of aspartate is enhanced.
Which of the following is true regarding the regulation of ATCase?
- ATCase requires one aspartate to produce carbamoyl aspartate.
- ATC requires one asparagine to produce carbamoyl asparagine.
- It is activated by CTP and ATP.
- It is inhibited by abundant aspartate.
- It is inhibited by ATP.
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Author of lecture Pyrimidine de novo Metabolism: ATCase Reaction
Kevin Ahern, PhD
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It was very clear and explained well- the subject itself is usually hard to explain
