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Overview – Antiviral Drugs

by Pravin Shukle, MD
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    Transcript

    00:00 Welcome to Pharmacology by Lecturio.

    00:03 I'm Dr.Parvin Shukle.

    00:05 We're going to be talking about antiviral agents.

    00:08 In order to understand how antiviral agents work, let's take a look at the mammalian cell.

    00:14 So this is represented by the big purple circle there.

    00:17 Now viruses attach and enter into the mammalian cell to start their replication process.

    00:24 We actually have drugs that can block viral entrance and attachment.

    00:29 And these are active in HIV disease or HSV disease or even respiratory syncytial viral diseases.

    00:37 Once the virus penetrates into the cell, we can actually block that step of penetration with interferon alpha agents.

    00:46 Interferon alpha agents are currently active in hepatitis B and hepatitis C infections.

    00:51 As the virus has penetrated into the cell, it now starts too uncoat itself.

    00:58 And that's in preparation for exposing it's RNA to the mammalian cell DNA.

    01:03 Now we can block the uncoating of virus cells by certain agents like amantadine.

    01:09 And these are commonly used in diseases like influenza.

    01:13 Now there are three phases of protein synthesis.

    01:17 There's early protein synthesis.

    01:20 There's nucleic acid synthesis and late protein synthesis.

    01:24 Nucleic acid synthesis is a huge category for us because it's blocked by multiple agents.

    01:30 There's reverse transcriptase and others that are active in things like cytomegalovirus, HIV, even in respiratory syncytial virus.

    01:42 Now the late protein synthesis and processing is also blocked by different types of agents called protease inhibitors.

    01:49 The next step of viral assembly is the packaging and assembly once the virus inculcated itself into the mammalian cell.

    02:00 That's how viruses are going to replicate.

    02:02 This can be blocked by CCRV's.

    02:05 And that's commonly used in HIV disease.

    02:08 And we're starting to do research in other viral diseases as well to effect this step.

    02:13 As the virus get's released from the cell, we can block these particular steps of viral release by the neuraminidase inhibitors.

    02:23 And that's most commonly used in influenza.

    02:26 But we're starting to do research in other areas as well.

    02:30 So there you have it, all of the viral agents are essentially placed on this slide and understand where they fit in.

    02:37 Let's go into more detail.

    02:40 I'm going to divide up antiviral agents into the diseases that they are active against.

    02:48 But we'll also talk about where in the cycle they're active too.


    About the Lecture

    The lecture Overview – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.


    Included Quiz Questions

    1. Viral release
    2. Early protein synthesis
    3. Fusion inhibitors
    4. Packaging and assembly
    5. Penetration
    1. Hepatitis B virus
    2. HIV
    3. RSV
    4. HSV
    5. Influenza

    Author of lecture Overview – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD


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