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Anti-Inflammatory Agents: Release Inhibitors and IgE-Antibodies

by Pravin Shukle, MD
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    00:01 Let's talk about mast cell inhibitors. We also call them degranulation inhibitors but now we have changed the name to just call them release inhibitor, so you may see one of those three names.

    00:12 Cromolyn is the prototypical agent in this drug class. It is an insoluble chemical and has minimal systemic absorption.

    00:20 It is rarely used now. And eye drop and nasal spray formulations are sometimes used for allergy to weed dust, what is commonly called hay fever.

    00:31 Not terribly effective and we don't really use them clinically either.

    00:35 Let's move on to IgE antibody mediated therapy. I have mentioned this type of therapy before.

    00:43 Monoclonal antibodies are completely changing the entire aspect of medicine.

    00:48 I mentioned some of the monoclonal antibodies in lipid control in my lipid lecture some time ago.

    00:55 IgE antibody mediated treatment like omalizumab is a humanized murine monoclonal antibody.

    01:05 It will bind to the IgE on sensitized mast cells. It prevents activation by asthma trigger antigens.

    01:13 Now, it is really expensive. It's in the tens of thousands of dollars.

    01:19 My gosh, it's really quite effective. These are once a week or once every two week injections.

    01:27 Some of the monoclonal antibodies in other treatment areas such as rheumatoid arthritis are given once every 3 months and we're expecting to see some of these agents come out for asthma that are given more rarely as well.

    01:41 This is a very exciting area of medicine. I can't wait to see what happens.

    01:45 And it's completely changing the way we treat asthma.


    About the Lecture

    The lecture Anti-Inflammatory Agents: Release Inhibitors and IgE-Antibodies by Pravin Shukle, MD is from the course Respiratory Pharmacology.


    Included Quiz Questions

    1. Humanized murine monoclonal antibody.
    2. Humanized equine monoclonal antibody.
    3. Upregulates the production of cAMP to relax and dilate smooth muscle.
    4. Passes through the cell and into the nucleus to directly augment DNA expression.
    5. Acetylcholine receptor agonist.

    Author of lecture Anti-Inflammatory Agents: Release Inhibitors and IgE-Antibodies

     Pravin Shukle, MD

    Pravin Shukle, MD


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