Here is a time course of the progression of
this disease that we've been describing: African
trypanosomiasis. You have on the left the
very beginning where the trypanosomes are
injected into the host, the development of
the chancre, fever and headache, early signs,
the parasites move into the lymphatics, continued
fever, swollen lymph nodes, deteriorating
health. We’re now months into the infection
and then at some point the parasite, depending
on which species it is, which subspecies,
months to years, it will invade the CNS, this
is associated initially with anorexia, minor
neurological problems, apathy and lassitude.
After more time, severe sleep disturbance
and severe neurological symptoms, finally
leading to convulsions, coma, other infections
and death. This is a lethal infection. Here
is a picture of a young boy with the typical
presentation of what is called sleeping sickness,
that is the disease caused by African trypanosomes.
He is lying in bed, he can't function at all,
he sleeps most of the time and whenever his
eyes are open he is simply staring into space.
This is a terrible affliction for which we
need really to devise preventatives.