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Abnormalities of the Development of the Gut – Stomach, Midgut and Hindgut Development

by John McLachlan, PhD
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    00:00 One possibility is that ectopic pancreatic tissue may be found in wrong places during the course of the body. And this may found in the variety of different places from the distal oesophagus up to the tip of the primary intestinal loop.

    00:16 Frequently however, little pieces of ectopic pancreas are found in the duodenum or in the mucosa of the stomach. If a Meckel’s diverticulum is present, Meckel’s diverticulum is the persistence of the yolk stalk which is covered in another lecture. Then this may contain pancreatic tissue, and this may be a fact on the development of a condition very similar to appendicitis. Obviously, the pancreas is undergoing a number of different movements and changes during this development. One circumstance which may arise is that the pancreatic bud may be branched, and therefore, lie on both sides of the gut. If this is the case, it may cause a constriction or even a complete occlusion of the duodenum. As a consequence, then the gut may be blocked at this level. The signs of this in newborn baby will be that the baby would regurgitate milk, and classically, this milk would be coloured by the bile pigments, so it would be greenish in colour. It may also be in atresia of the ducts, which means that effectively, the bile pigments and salts kind of make their way into the intestine. So this can cause an infection to develop, and, of course, the individual would be jaundiced as a consequence. In a serious example to this condition, a liver transplant might be required. So then, in summary, we’ve looked at the development of the liver and the gall bladder and the pancreas, the spleen, unusually derived from the mesoderm, and some abnormalities of these systems. Thank you.


    About the Lecture

    The lecture Abnormalities of the Development of the Gut – Stomach, Midgut and Hindgut Development by John McLachlan, PhD is from the course System-Specific Embryology with John McLachlan.


    Author of lecture Abnormalities of the Development of the Gut – Stomach, Midgut and Hindgut Development

     John McLachlan, PhD

    John McLachlan, PhD


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